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Additionally, it has been noted that metabolic activity in NEPC tumors differs from metabolism in AR-driven adenocarcinoma tumors
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While some trials show no major changes in BMD, others suggest slight improvements in bone turnover markers: Trials of liraglutide and exenatide generally show stable BMD over 6–12 months Certain populations — such as postmenopausal women or individuals with rapid weight loss — may show changes in bone markers like osteocalcin and P1NP However, most of these studies are small, short-term, or not powered for skeletal endpoints
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